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Mortality, clinical findings, predisposing factors and treatment of Clostridioides difficile colitis in Japanese thoroughbred racehorses
- Source :
- Veterinary Record. 187
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background Although Clostridioides difficile-associated diseases (CDAD) is considered to be associated with colitis in horses, few studies have been performed with a focus on the characteristics of CDAD in thoroughbred racehorses. Methods Between 2010 and 2018, a test for C. difficile was performed using faecal samples from 137 thoroughbred racehorses with colitis presenting with diarrhoea and fever. The mortality rate, clinical findings, predisposing factors and the selected treatments were investigated in a retrospective manner. Results Twenty-four cases were diagnosed as CDAD and 113 as non-CDAD. The mortality rate was significantly higher in the CDAD group (83 per cent) than that in the non-CDAD group (34 per cent). The levels of serum amyloid A, blood urea nitrogen and packed cell volume at initial presentation were also significantly higher, and those of total protein and albumin were significantly lower in the CDAD group. The development of CDAD was associated with the administration of antimicrobials, surgery and hospitalisation. No significant improvement in mortality was observed for any of the selected treatment in both groups. Conclusion CDAD in thoroughbred racehorses was identified as a high mortality disease with rapid progression of systemic inflammation and deterioration of the circulatory state. Further investigation is required to improve the treatment.
- Subjects :
- medicine.medical_specialty
General Veterinary
040301 veterinary sciences
business.industry
Mortality rate
0402 animal and dairy science
04 agricultural and veterinary sciences
General Medicine
Disease
bacterial infections and mycoses
medicine.disease
Systemic inflammation
040201 dairy & animal science
0403 veterinary science
Internal medicine
Medicine
Serum amyloid A
Colitis
medicine.symptom
business
Blood urea nitrogen
Clostridioides
Total protein
Subjects
Details
- ISSN :
- 20427670 and 00424900
- Volume :
- 187
- Database :
- OpenAIRE
- Journal :
- Veterinary Record
- Accession number :
- edsair.doi...........9dec37ab39b3b2228087d681a888e5dc