Development of ceramide and honey based biodegradable hydrogel dressing’s materials for the application to burn skin

Ceramide is well known for its skin barrier function where hydrogel is an ideal one for wound healing, on the other hand honey is used for antibacterial activity and burn wound treatment from many years ago. So our aim to develop a ceramide loaded honey based hydrogel biomaterial for burn wound healing. The biomedical hydrogel biomaterial have been prepared by solution casting method. The developed Hydrogel membranes were characterized by using Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM) and UV- Vis Spectrophotometer. Besides that, swelling behavior in physiological solution, moisture retention capability, gel fraction, water vapor transmission rate (WVT), porosity and antimicrobial study were also evaluated. After all the hydrogel were evaluated for burn wound healing activity in mice model. Ceramide Hydrogel (C2) & Ceramide & Honey Hydrogel (CH) showed significant wound healing rate but only CH hydrogel showed significant antibacterial activity against Staphallycoccus aureus bacteria. Other physicochemical, swelling, WVT, porosity, gel fraction, weight loss, and FTIR, FESEM & UV study was very satisfactory and all experimented data strongly support the use of the hydrogel membrane as a burn wound healing.