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Atypical Early-Onset Alzheimer's Disease Dementia Diagnosed by Biomarker Study
- Source :
- Dementia and Neurocognitive Disorders. 14:168
- Publication Year :
- 2015
- Publisher :
- Korean Dementia Association, 2015.
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Abstract
- Background The described clinical characteristics of early-onset Alzheimer’s disease (EOAD) are distinct from that of late-onset AD. We reported a patient with atypical EOAD. Case Report A 54-year-old, truck driver developed gradual visuospatial, language and calculation deficits for 3 months. The neuropsycho logical impairments were extensive. Brain MRI revealed asymmetric atrophy in left medial temporal lobe along with distinct widening of syl vian fissure. (18)F-florbetapir-positron emission tomography (PET) showed a high uptake in the cortex. Further, the profiles of cerebrospinal fluid (CSF) biomarker were compatible with AD. Conclusions We diagnosed the patient as EOAD based on the result of biomarker study. Increased As burden was identified through am yloid PET imaging and decreased CSF Aβ level. The high rise of CSF Tau proteins was in agreement with the patient’s extensive and rapid cognitive decline. This case report demonstrates the importance of AD biomarker study in confronting early-onset dementia with atypical clinical presentation.
Details
- ISSN :
- 23840757 and 17381495
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Dementia and Neurocognitive Disorders
- Accession number :
- edsair.doi...........9d69f1cb7821f901e8b283f12f89a872