Back to Search Start Over

Hot-melt co-extrusion technology as a manufacturing platform for anti-hypertensive fixed-dose combinations

Authors :
Shu Li
Zoe Senta-Loys
Anne Marie Healy
Gareth C. Gilvary
Ammar Almajaan
Yiwei Tian
David S. Jones
Gavin Andrews
Jeremiah Kelleher
Source :
British Journal of Pharmacy. 4
Publication Year :
2019
Publisher :
University of Huddersfield Press, 2019.

Abstract

This work focused on the development of a concentric multi-layered fixed-dose combination via an advanced manufacturing technique, hot-melt co-extrusion. The dosage form was designed to offer differing release behaviour; immediate and sustained release from the coat and core, respectively. Hydrochlorothiazide and losartan potassium were incorporated as anti-hypertensive drugs. Solid-state characterisation revealed that both were transformed into their amorphous forms. In-vitro dissolution testing showed desired release performances offering both immediate and modified release.

Details

ISSN :
20588356
Volume :
4
Database :
OpenAIRE
Journal :
British Journal of Pharmacy
Accession number :
edsair.doi...........9d66bea9e29ba4dc7e7cb8149bd7cff0
Full Text :
https://doi.org/10.5920/bjpharm.596