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A chiroptical approach for the absolute stereochemical determination of P-stereogenic centers
- Source :
- Chemical Science. 12:1750-1755
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- A simple chiroptical solution for the absolute stereochemical determination for asymmetric phosphorus V stereocenters is presented. Strong coordination of the phosphorus oxide with the Zn-metallo center of the racemic host Zn-MAPOL 2 leads to an induced axial chirality of the host, yielding a strong ECCD signal. A mnemonic is proposed to correlate the asymmetry of the guest molecule with the observed ECCD signal.
Details
- ISSN :
- 20416539 and 20416520
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Chemical Science
- Accession number :
- edsair.doi...........9d1e6c85dc511bfbefb0055b3cf9dcce