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VcR-CVAD induction chemotherapy followed by maintenance rituximab in mantle cell lymphoma: a Wisconsin Oncology Network study
- Source :
- British Journal of Haematology. 155:190-197
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Summary Intensive chemotherapy regimens are not feasible in many adults with mantle cell lymphoma (MCL). We sought to build upon our previous experience with a non-intensive regimen, modified R-hyperCVAD chemotherapy (rituximab, cyclophosphamide, vincristine, doxorubicin, dexamethasone) with maintenance rituximab (MR), by the incorporation of bortezomib (VcR-CVAD) and the extension of MR beyond 2 years. Patients with previously untreated MCL received VcR-CVAD chemotherapy every 21 d for six cycles. Patients achieving at least a partial response to induction chemotherapy received rituximab consolidation (375 mg/m2 × 4 weekly doses) and MR (375 mg/m2 every 12 weeks × 20 doses). The primary end points were overall and complete response (CR), and secondary endpoints were progression-free (PFS) and overall survival (OS). Thirty patients were enrolled, with a median age of 61 years. All patients had advanced stage disease, and 60% had medium/high MCL International Prognostic Index risk factors. A CR or unconfirmed CR was achieved in 77% of patients. After a median follow-up of 42 months, the 3-year PFS and OS were 63% and 86%, respectively. The observed 3-year PFS and OS with VcR-CVAD in MCL were comparable to reported outcomes with more intensive regimens. A cooperative group trial (E1405) is attempting to replicate these promising results.
- Subjects :
- Oncology
Vincristine
medicine.medical_specialty
Chemotherapy
Cyclophosphamide
business.industry
medicine.medical_treatment
Induction chemotherapy
Hematology
medicine.disease
Regimen
International Prognostic Index
hemic and lymphatic diseases
Internal medicine
medicine
Mantle cell lymphoma
Rituximab
business
medicine.drug
Subjects
Details
- ISSN :
- 00071048
- Volume :
- 155
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi...........9cdba6425dfbad3f6daa5dc3ac0c600f