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The Protective Effects of Protein-Enriched Fraction from Housefly (Musca domestica) against Aged-Related Brain Aging
- Source :
- Journal of Nutritional Science and Vitaminology. 66:409-416
- Publication Year :
- 2020
- Publisher :
- Center for Academic Publications Japan, 2020.
-
Abstract
- The Musca domestica larvae are well known for its multifunctions and great nutritional value. The present study aimed at investigating the beneficial effect of Musca domestica larvae extract (Mde) against memory impairment, structural damage and oxidative stress in aged rats. Twenty-month-old rats were gavaged with Mde for 2 mo. Morris Water Maze test indicated Mde prevented aging-induced spatial learning and memory dysfunction in the aged rats. Mde supply was also found to attenuate age-associated changes of brain histology that observed by light microscopy and transmission electron microscopy. Moreover, the increase of antioxidant capacity, glutathione peroxidase (GPx) activity, superoxide dismutase (SOD) activity, as well as the decreased methane dicarboxylic aldehyde (MDA) levels, were consistent with these results. Hence, we propose that oral administration of Mde could improve memory impairment via antioxidant action, and Mde has the potential to act as an excellent food supplement or medicine for the attenuation of brain aging.
- Subjects :
- chemistry.chemical_classification
medicine.medical_specialty
animal structures
Nutrition and Dietetics
Antioxidant
biology
Glutathione peroxidase
medicine.medical_treatment
Medicine (miscellaneous)
Morris water navigation task
biology.organism_classification
medicine.disease_cause
Superoxide dismutase
Endocrinology
chemistry
Oral administration
Internal medicine
medicine
biology.protein
Memory impairment
Housefly
Oxidative stress
Subjects
Details
- ISSN :
- 18817742 and 03014800
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Journal of Nutritional Science and Vitaminology
- Accession number :
- edsair.doi...........9c544a54a0f3ae1a8a72a3a7bd8a6130