Association between circulating microRNA-122, microRNA-126-3p and microRNA-146a and inflammatory markers in patients with pre-diabetes and type 2 diabetes mellitus v1

Ninety individuals were included in this case-control study:30 type 2 diabetes mellitus, 30 pre-diabetes and 30 healthy individuals (males and females, age: 25-65, body mass index: 25-35). MicroRNAs expression was determined by real-time polymerase chain reaction. Furthermore, plasma concentrations of tumor necrosis factor alpha (TNF-α) and interleukin 6 (Il-6) and fasting insulin was measured by enzyme-linked immunosorbent assay. Homeostatic model assessment for insulin resistance (HOMA-IR) was calculated as an indicator of insulin resistance.