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Synthetic studies toward longeracemine: The intramolecular [4+2] cycloaddition of 3H-pyrroles
- Source :
- Tetrahedron. 74:4539-4549
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Model studies to develop a tetracyclization approach mimicking the proposed biosynthesis of the secodaphnane-type alkaloid longeracemine are described. These studies have culminated in the successful implementation of a 3H-pyrrole [4+2] cycloaddition that delivers a longeracemine-like azabicycle containing three contiguous quaternary stereocenters.
Details
- ISSN :
- 00404020
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi...........9c5271630bd1f35b79bb4e63440bfc26