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945-P: Elevated Blood Pressure in Pregnant Women with Gestational Diabetes According to the WHO Criteria: Importance of Obesity
- Source :
- Diabetes. 70
- Publication Year :
- 2021
- Publisher :
- American Diabetes Association, 2021.
-
Abstract
- Objective: Hypertension before and during early pregnancy has been associated with an increased risk of gestational diabetes mellitus (GDM) in retrospective analyses. We investigated the prospective blood pressure patterns in a population-based cohort of pregnant women, who were stratified according to their metabolic status in early 3rd trimester. Research Design and Methods: We recorded blood pressure longitudinally during pregnancy in 1,230 women from the Odense Child Cohort, Denmark. Fasting glucose and insulin were measured at gestational weeks 28-30. Metabolic status was evaluated according to the World Health Organization (WHO) 2013 threshold for GDM (GDM-WHO: fasting plasma glucose ≥5.1 mmol/l), insulin and homeostatic model assessment of insulin resistance (HOMA-IR). Relationships between metabolic status in 3rd trimester and blood pressure trajectories throughout pregnancy were evaluated with adjusted linear mixed models. Results: GDM-WHO prevalence was high, 40% (498/1,230). Significant associations between GDM-WHO and blood pressure were seen only in overweight women, with 2.48 (1.08; 3.88) mmHg higher systolic and 1.58 (0.57; 2.58) mmHg higher diastolic trajectories in women with GDM-WHO compared with differences of -0.38 (-1.51; 0.75) and 0.03 (-0.83; 0.89) mmHg in lean women with GDM-WHO. The associations were independent of progression to gestational hypertension. Blood pressure trajectories in pregnancy were elevated across insulin and HOMA-IR quartiles. Conclusions: GDM-WHO was associated with moderate elevations of blood pressure troughout pregnancy. The relationships were independent of progression to overt gestational hypertension, but largely modified by overweight status. Disclosure A. Birukov: None. R. Dechend: None. M. S. Andersen: None. D. Glintborg: None. M. B. Schulze: None. T. K. Jensen: None. L. B. Andersen: None. K. Kräker: None. E. Polemiti: None. B. L. Jensen: None. J. S. Joergensen: None. Funding German Ministry of Education and Research; State of Brandenburg (82DZD00302)
- Subjects :
- Gestational hypertension
Pregnancy
education.field_of_study
medicine.medical_specialty
business.industry
Obstetrics
Endocrinology, Diabetes and Metabolism
Population
Overweight
medicine.disease
Gestational diabetes
Blood pressure
Insulin resistance
Internal Medicine
medicine
Homeostatic model assessment
medicine.symptom
business
education
Subjects
Details
- ISSN :
- 1939327X and 00121797
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi...........9c4d3114683e7ca731e4b8e486ba7346
- Full Text :
- https://doi.org/10.2337/db21-945-p