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Possible Sites of Therapeutic Action in Restless Legs Syndrome: Focus on Dopamine and α2δ Ligands
- Source :
- European Neurology. 66:18-29
- Publication Year :
- 2011
- Publisher :
- S. Karger AG, 2011.
-
Abstract
- Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by abnormal sensations that occur primarily at rest or during sleep, which are alleviated by movement of the affected limb. The pathophysiology of RLS remains unclear, although roles for dopamine dysfunction and brain iron deficiency have been proposed. The hypothalamic A11 dopaminergic circuit is used to explain the dopamine dysfunction in RLS and the potential therapeutic actions of dopamine D2 agonists. Modulation of central and peripher- al neuronal circuits may also explain the potential therapeutic sites of action of opioids, adenosine receptor ligands, and voltage-gated calcium channel α2δ ligands in RLS. The known and possible therapeutic benefits of these agents and their relationship to dopaminergic dysfunction in RLS are discussed in this review.
- Subjects :
- medicine.medical_specialty
business.industry
Calcium channel
Dopaminergic
Adenosine A2A receptor
medicine.disease
Adenosine receptor
Pathophysiology
Endocrinology
Neurology
Dopamine
Internal medicine
mental disorders
medicine
Neurology (clinical)
Restless legs syndrome
business
Receptor
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 14219913 and 00143022
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- European Neurology
- Accession number :
- edsair.doi...........9bc185687c1d84993758ece9be8ff85b