ChemInform Abstract: 3-Hydroxy-2,2-dimethylimidazolidin-4-one: The Regioselective Synthesis and Chiral Crystallization

The condensation of glycine hydroxamic acid with acetone regioselectively leads to the formation of the title achiral cyclic hydroxamic acid, which crystallises from an acetone solution as chiral crystals (space groupP2 1 2 1 2 1 ) of (P,1R,3S) and (M,1S,3R) enantiomers.