Hemoglobin versus ADAMTS13

Authors :: David G. Motto
Source :: Blood. 105:436-437
Publication Year :: 2005
Publisher :: American Society of Hematology, 2005.
Abstract: Comment on Studt et al, page [542][1] Free hemoglobin inhibits ADAMTS13 activity in vitro, demonstrating a potential source of artifact affecting ADAMTS13 activity assays and inhibitor screens. Deficiency of the ADAMTS13 metalloprotease causes thrombotic thrombocytopenic purpura (TTP). The rare