LB-004 Sex differences in acute stroke thrombectomy management and outcomes in the united states: evidence from the NVQI-QOD registry

Introduction Endovascular mechanical thrombectomy is the standard of care treatment for acute ischemic stroke secondary to large vessel occlusions, but racial disparities in stroke interventional management and outcomes are not well studied. Moreover, a robust analysis of multiple relevant variables, with consideration of possible confounders, has not been previously conducted. We aimed to evaluate real-world evidence for racial differences in stroke thrombectomy management, short- and long-term outcomes using the Neurovascular Quality Initiative-Quality Outcomes Database (NVQI-QOD) registry. Methods Data from the NVQI-QOD registry database were analyzed and compared for racial differences with respect to technical and functional outcomes of stroke thrombectomy in 3281 patients from 23 US centers (17 states) between Jan 2015 to March 2020. Race was classified into 4 groups: 1) Caucasian (n=2484), 2) African American (n=563), 3) Hispanic (n=109), and 4) Asian (n=105). Analysis of variances (ANOVAs), Chi-square tests, Mann Whitney U tests, and multivariate regression models were used to assess racial disparities for 10 outcome variables: final thrombolysis in cerebral infarction (TICI) grade (n=3182), 24 hour NIH stroke score (NIHSS) (n=2850), post-procedure length of stay (n=3257), ICU days (n=2787), in-hospital mortality (n=3259), discharge status (n=3281), discharge NIHSS (n=2426), discharge modified Rankin score (mRS) (n=996), 90 day re-admission rate (n=416), and 90 day mRS (n=1184). Regression models controlled for demographics, comorbidities, intravenous tPA thrombolysis, and pre-stroke functional measures. Results ANOVA and Chi-square tests revealed significant differences between racial group means including post-procedure length of stay (p Conclusion Evidence from the NVQI-QOD registry suggests that there are several racial disparities in stroke thrombectomy management and outcomes, with minorities exhibiting increased post-procedural NIHSS, length of stay, and ICU days. Although African Americans were noted to suffer less in-hospital mortality compared to Caucasians, this did not translate into increased odds of a favorable clinical outcome at 90 days. Disclosures V. Thirunavu: None. R. Abdalla: None. D. Cantrell: None. M. Hurley: None. A. Shaibani: None. B. Jahromi: None. M. Potts: None. S. Ansari: None. O. NVQI-QOD Registry: None.