422 Dsg2 increases exosome release and enhances EGFR/c-Src content: A mechanism for an intercellular mitogenic effect

Dsg2 increases exosome release and enhances EGFR/c-Src content: A mechanism for intercellular mitogenic effect Andrew M. Overmiller1*, Jennifer A. Pierluissi1+, Peter J. Wermuth1, Ubaldo Martinez-Outschoorn2, Madalina Tuluc3, Adam Luginbuhl3, Joseph Curry3, Larry A. Harshyne4, James K. Wahl, III5, Andrew P. South1 and Mỹ G. Mahoney1 1Department of Dermatology & Cutaneous Biology,, 2Department of Medical Oncology, 3Department of Otolaryngology-Head and Neck Surgery, 4Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA, USA, 5Department of Oral Biology, University of Nebraska, Lincoln, NE, USA *Gene%cs, Genomics, and Cancer Biology Graduate Program; +Cell and Developmental Biology Graduate Program ABSTRACT