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Endocrine function in bronchial asthma and hay fever
- Source :
- Journal of Allergy. 29:384-395
- Publication Year :
- 1958
- Publisher :
- Elsevier BV, 1958.
-
Abstract
- A controlled study of 17-ketosteroid and 11-oxysteroid excretion in ambulatory patients with bronchial asthma has been carried out during intervals when the patients had been without steroid medication for at least two weeks. No significant correlation was noted between steroid excretion and the asthmatic state as verified by serial timed vital capacities and daily score sheets. No significant correlation was noted between 17-ketosteroid excretion and 11-oxysteroid excretion. Total 11-oxysteroid excretion was not abnormal in bronchial asthma. Significant reduction of total 17-ketosteroids was found in both male and female asthmatic patients, as compared to age- and sex-matched controls, but not in patients with hay fever. Fractional 17-ketosteroid excretion as measured by androsterone-glucuronide and etiocholanolone-glucuronide analyses tended to confirm total 17-ketosteroid excretion. The administration of cortisone resulted in a further decrease of androsterone-glucuronide and etiocholanolone-glucuronide excretion for the duration of therapy.
- Subjects :
- medicine.medical_specialty
business.industry
Physiology
General Medicine
medicine.disease
Excretion
chemistry.chemical_compound
Endocrinology
chemistry
Internal medicine
Ketosteroid
Ambulatory
polycyclic compounds
medicine
Endocrine system
Hay fever
Cortisone
business
hormones, hormone substitutes, and hormone antagonists
Oxysteroid
medicine.drug
Asthma
Subjects
Details
- ISSN :
- 00218707
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy
- Accession number :
- edsair.doi...........9ade8de8339c0d84040efbb3bd1c691b
- Full Text :
- https://doi.org/10.1016/0021-8707(58)90081-9