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Endocrine function in bronchial asthma and hay fever

Authors :
Alan L. Michelson
Herbert H. Wotiz
Francis C. Lowell
Phyllis Kravetz
Henry M. Lemon
Source :
Journal of Allergy. 29:384-395
Publication Year :
1958
Publisher :
Elsevier BV, 1958.

Abstract

A controlled study of 17-ketosteroid and 11-oxysteroid excretion in ambulatory patients with bronchial asthma has been carried out during intervals when the patients had been without steroid medication for at least two weeks. No significant correlation was noted between steroid excretion and the asthmatic state as verified by serial timed vital capacities and daily score sheets. No significant correlation was noted between 17-ketosteroid excretion and 11-oxysteroid excretion. Total 11-oxysteroid excretion was not abnormal in bronchial asthma. Significant reduction of total 17-ketosteroids was found in both male and female asthmatic patients, as compared to age- and sex-matched controls, but not in patients with hay fever. Fractional 17-ketosteroid excretion as measured by androsterone-glucuronide and etiocholanolone-glucuronide analyses tended to confirm total 17-ketosteroid excretion. The administration of cortisone resulted in a further decrease of androsterone-glucuronide and etiocholanolone-glucuronide excretion for the duration of therapy.

Details

ISSN :
00218707
Volume :
29
Database :
OpenAIRE
Journal :
Journal of Allergy
Accession number :
edsair.doi...........9ade8de8339c0d84040efbb3bd1c691b
Full Text :
https://doi.org/10.1016/0021-8707(58)90081-9