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Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme
- Source :
- Acta Neurologica Scandinavica. 122:159-167
- Publication Year :
- 2010
- Publisher :
- Hindawi Limited, 2010.
-
Abstract
- Helseth R, Helseth E, Johannesen TB, Langberg CW, Lote K, Ronning P, Scheie D, Vik A, Meling TR. Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme. Acta Neurol Scand: 122: 159–167. © 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard. Objectives – To study overall survival (OS), prognostic factors, and repeated surgery in glioblastoma multiforme (GBM). Material and methods– Retrospective study of 516 consecutive adult patients who underwent primary surgery for a GBM in year 2003–2008. Results – Median age at primary surgery was 63.7 years (range 18.0–88.0). Median OS was 9.9 months. Age >60 years, poor preoperative ECOG score, bilateral tumor, biopsy rather than resection, and no temozolomide chemoradiotherapy were negative risk factors. Repeat surgery was performed in 65 patients (13%). Median time between first and second surgery was 7 months. Indications for second surgery were increasing neurological deficits (35.4%), raised ICP (33.8%), asymptomatic but reoperated because of tumor progression verified on MRI (20.0%), and epileptic seizures (11%). Patients who underwent repeated surgery had longer OS; 18.4 months vs 8.6 months (P
- Subjects :
- medicine.medical_specialty
Temozolomide
medicine.diagnostic_test
Proportional hazards model
business.industry
Retrospective cohort study
General Medicine
medicine.disease
Asymptomatic
Surgery
Central nervous system disease
Neurology
Biopsy
medicine
Neurology (clinical)
Young adult
medicine.symptom
business
Chemoradiotherapy
medicine.drug
Subjects
Details
- ISSN :
- 00016314
- Volume :
- 122
- Database :
- OpenAIRE
- Journal :
- Acta Neurologica Scandinavica
- Accession number :
- edsair.doi...........9abc5bc7877ab742619db6091f85db32