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Animal Models for Melioidosis
Animal Models for Melioidosis
- Source :
- Current Tropical Medicine Reports. 4:208-222
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Development, testing, and evaluation of medical countermeasures for melioidosis are hampered by a lack of well-characterized and standardized animal models. Recent work has both refined existing animal models for this disease and identified new ones. Head-to-head comparisons of mouse strains with varying susceptibility to the organism and using different routes of infection highlighted and confirmed important similarities and differences between murine models and exposure routes. Diabetic mouse models provided insight into the disease process in humans having this major risk factor. Large animal models, both livestock and non-human primate, have been established. Alternative (non-mammalian) models have been useful in identification of virulence factors and screening of therapeutic candidates. They hold potential for large-scale screening that would not be appropriate or practical for mammalian species. Recent advances in animal and alternative modeling will enhance our understanding of the organism and the disease process, as well as accelerating the development of medical countermeasures.
- Subjects :
- 0301 basic medicine
Melioidosis
Burkholderia pseudomallei
Diabetic mouse
Computational biology
Disease
Biology
medicine.disease
biology.organism_classification
03 medical and health sciences
030104 developmental biology
Infectious Diseases
medicine
Immunology and Allergy
Disease process
Identification (biology)
Organism
Large animal
Subjects
Details
- ISSN :
- 21963045
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Current Tropical Medicine Reports
- Accession number :
- edsair.doi...........9a8a9053d4a790fe6859074b1a9d1e2b
- Full Text :
- https://doi.org/10.1007/s40475-017-0131-5