Retinal pathology in multiple sclerosis: insight into the mechanisms of neuronal pathology

Sir, We congratulate Calabresi et al . (2010) for the scientific commentary regarding retinal pathology in multiple sclerosis. The authors have excellently summarized the pathological mechanism in multiple sclerosis in the brain and retina. We would like to make a contribution to the retinal aspects of their comments. Full-field flash electroretinogram is the mass electrical activity of the retina to a flash of light. Pattern electroretinogram reflects the retinal response to a structured, contrast-reversal stimulus, mostly a checkerboard pattern. There have been many studies investigating the functional and structural retinal changes in the retinas of patients with multiple sclerosis. Mostly, optical coherence tomography has been used to explore the structural changes that show retinal nerve fibre layer thinning. This change was …