EVALUATION OF RISK FACTORS AFFECTING RECURRENCE AND PROGRESSION AFTER BCG THERAPY IN NON-MUSCLE INVASIVE BLADDER CANCER

Objective: The study was conducted to evaluate the risk factors associated with recurrence and progression in high-risk non muscle-invasive bladder cancer (NMIBC) patients treated with intravesical Bacillus Calmette Guerin (BCG). Methods: We retrospectively analysed 101 patients who underwent intravesical BCG for high-risk NMIBC from 2006-2015. Multiple factors such as age, sex, smoking status, prior recurrence rate, high-risk group, tumour size and tumour extent were tested as risk factors for recurrence and progression. We also assessed the probabilities of recurrence and progression after BCG therapy using CUETO (Spanish Urological Club for Oncological Treatment) Scoring model. Results: Total of 93 males (92.1%) and 8 females (7.9%) were enrolled in our study. Over a median follow up of 24 mo, fifteen patients had a recurrence and six patients had progression after BCG therapy. Both univariate and multivariate analysis shows prior recurrence rate and high-grade tumour as a significant factor for tumour recurrence (p=