A 55-Year-Old Male with Right Foot Weakness

Hereditary neuropathies are common. They are often diagnosed when another medical issue begins, for example, orthopedic foot problems or chemotherapy that causes a persistent severe neuropathy. Our patient developed a peroneal neuropathy after a long international airline flight. Initially it was thought to be related to lumbosacral radiculopathy. Careful history, neurological examination, and electrodiagnostic testing was helpful in pointing to a peroneal neuropathy rather than a lumbosacral radiculopathy. Family history in evaluating patients with peripheral neuropathy is essential. The actual examination and testing of relatives may be necessary. Genetic testing for the confirmation of the diagnosis of hereditary neuropathy is outlined. Clinical features of the most common hereditary peripheral are listed. It is important to recognize that a patient has a hereditary neuropathy before therapy with a chemotherapeutic agent is initiated.