Solvent-Free Synthesis of Indole-Based Thiosemicarbazones under Microwave Irradiation

A rapid, efficient and environmentally friendly methodology has been developed for the synthesis of indole-3-carboxaldehyde thiosemicarbazones by using aluminum oxide as the solid support under microwave assisted solvent-free conditions. Compared with the conventional heating method, this method gave the target products in good yield.