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Exacerbations of Chronic Obstructive Pulmonary Disease Tool to assess the efficacy of acute treatment
- Source :
- International Journal of Chronic Obstructive Pulmonary Disease. 14:471-478
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Background and objective The Exacerbations of Chronic Obstructive Pulmonary Disease Tool-Patient-Reported Outcomes (EXACT-PRO) has been suggested as a reliable and valid measure for early assessment of COPD exacerbations and perceived recovery. However, there has been no evidence for EXACT-PRO efficacy in assessing recovery from treatment in a randomized controlled trial. The study evaluated the reliability, validity, and responsiveness of EXACT-PRO for the evaluation of the efficacy of acute treatment in patients with COPD exacerbation. Methods In a Phase III randomized controlled study for assessing the efficacy of antibiotic treatment on COPD exacerbation, EXACT-PRO was evaluated in the responders and non-responders. Results A total of 295 patients were analyzed (259 responders and 37 non-responders). Cronbach's α was 0.96 for EXACT total, 0.96 for the breathlessness domain, 0.89 for the cough and sputum domain, and 0.93 for the chest symptoms domain. The EXACT score correlated with the COPD assessment test (CAT) score (r=0.8, P
- Subjects :
- COPD
medicine.medical_specialty
Exacerbation
business.industry
Pulmonary disease
General Medicine
medicine.disease
law.invention
03 medical and health sciences
0302 clinical medicine
030228 respiratory system
Randomized controlled trial
Cronbach's alpha
law
Internal medicine
medicine
Sputum
In patient
030212 general & internal medicine
medicine.symptom
business
After treatment
Subjects
Details
- ISSN :
- 11782005
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- International Journal of Chronic Obstructive Pulmonary Disease
- Accession number :
- edsair.doi...........9932f869c29d286a0c78aead2a34abcf