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ChemInform Abstract: An Oxazoline-Mediated Synthesis of the Pyrrolophenanthridine Alkaloids and Some Novel Derivatives
- Source :
- ChemInform. 27
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- An unsymmetrical biaryl coupling between the Grignard of N-benzyl-7-bromoindoline 25 and the appropriately substituted (o-methoxyaryl)oxazoline 15 leads to an intermediate biaryl which can be elaborated in one step to the 1H-pyrrolo[3,2,1-de]phenanthridine ring system. This simple two-step sequence provides general access to the pyrrolophenanthridine alkaloids 2−6.
Details
- ISSN :
- 09317597
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........99136dfd6ecf30ba632aa77eb4503bd3