Rapid Advances in the Field of Epigenetics

Epigenetic regulations have been known as phenomena such as the X chromosome inactivation since the mid-twentieth century. Recently, DNA methylation and post-translational modification on histones, which consist chromatin, have been proved to mediate the epigenetic regulations. Then, DNA methyltransferases and histone deacetylases have been implicated in carcinogenesis to be attractive drug targets.