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ChemInform Abstract: Synthesis and Antimicrobial Properties of New Cepham and Penam Derivatives with the Carboxylic Group in the 'Wrong' β-Configuration
- Source :
- ChemInform. 21
- Publication Year :
- 1990
- Publisher :
- Wiley, 1990.
-
Abstract
- The cepham (9) and the penam (10) derivatives, with their carboxylic group in the “wrong” β-configuration, which is opposite to that exhibited by the common penicillins, were synthesized and assayed in vitro for antimicrobial properties. Compounds 9 and 10 , tested on Gram-positive and Gram-negative bacteria, both sensitive and resistant to β-lactamase inactivation, exhibited a very poor activity, directed only against non-β-lactamase-producing Gram-positive bacteria. One of the possible explanations for these results may be found in unfavourable steric and electronic effects deriving from the α-oriented methoxy group which is adjacent to the pharmacophoric carboxylic function.
Details
- ISSN :
- 09317597
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........98e1f4b5b993015922f0c6caaa85f19f