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Favorable Outcome of Patients with C-Viral Liver Disease Treated with Interferon
- Source :
- Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma ISBN: 9784431679752
- Publication Year :
- 2004
- Publisher :
- Springer Japan, 2004.
-
Abstract
- Hepatitis C virus related liver disease is one of the major cause of death in Japan. To evaluate the effect of interferon (IFN) therapy on survival, the prognosis of 459 patients with C-viral liver disease was examined. During the mean follow-up period of 8.2 years, 33 (9%) of 355 IFN-treated and 15 (14%) of 104 untreated patients died. Liver-related death, especially by HCC, was the main cause of death. IFN treatment decreased the risk for overall death to approximately a half and that for liver-related death to one fifth compared to untreated patients. The standardized mortality ratio for liver-related death was reduced to 0.4 by the IFN-treatment. This reduction was prominent in sustained virological responders. Thus, a long-term clinical benefit was expected from IFN therapy by reducing liver-related death, especially in sustained virological responders.
Details
- ISBN :
- 978-4-431-67975-2
- ISBNs :
- 9784431679752
- Database :
- OpenAIRE
- Journal :
- Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma ISBN: 9784431679752
- Accession number :
- edsair.doi...........9878a19875cf3380850416a0da120bd6