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Mutagenic activities of simple nitrofuran derivatives
- Source :
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 81:21-26
- Publication Year :
- 1981
- Publisher :
- Elsevier BV, 1981.
-
Abstract
- Several simple furan and nitrofuran compounds were tested for mutagenicity and related biological activities, in the Ames test, the bacterial repair test, the prophage-induction test and the chloroplast-bleaching test. Only those compounds having the nitro-group were found to be active in the test. If the nitro-group was in the β instead of in the α position, the mutagenic activity was much reduced (0.3 revertants per nanomole, the other simple nitrofurans producing 5–15 reversions per nanomole, as did 5-nitrofuran and 5,2-dinitrofuran). The vinyl-group-containing compound, 5-nitro-2-furylacrylic acid, was by one decadic order more effective both in the Ames test and in the prophage-induction test. In the repair tests all nitrofurans displayed a much higher dependence on the recA-repair system than on the uvrA system. For 2 compounds, the dinitrofuran and, especially, the 5-nitrofuraldehyde, the uvrA cells were even less sensitive than the wild-type cells.
Details
- ISSN :
- 00275107
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- Accession number :
- edsair.doi...........98391818de58475437fd957d659a6a5e