The Use of Fibrin Sealant (Tissucol/Tisseel) in Periodontal Surgery: Clinical and Histological Evaluation

The use of fibrin sealant (Tissucol) in periodontal surgery was tested in animal experiments, which showed an increase in the number of fibroblasts in the wound 3 days after surgery. No delay in wound healing was found on histologic sections. A clinical evaluation was also carried out, with a split-mouth design at first, and as a standard procedure later. Follow-up of 128 patients up to 3 years showed no adverse effect attributable to Tissucol. Instead hemostatic and adhesive qualities of the system facilitated surgery and shortened operating times, while wound healing appeared better in the first postoperative days.