Back to Search Start Over

Reaction profile in patch testing with allergens formed during vulcanization of rubber

Authors :
Cecilia Svedman
Christer Hansson
Ann Pontén
Ola Bergendorff
Source :
Contact Dermatitis. 70:300-308
Publication Year :
2014
Publisher :
Wiley, 2014.

Abstract

Summary Background Vulcanization of rubber changes its allergen pattern. Objectives To estimate the contact allergic reactivity profile of users of finished rubber products. Methods Twenty-four patients with known contact allergy to rubber accelerators were patch tested with 21 compounds found in chemical analyses of vulcanized rubber products. No diphenylguanidine, p-phenylenediamine antioxidants or thioureas were included in the study. Results Thiuram monosulfides formed during vulcanization showed generally stronger test reactions than the corresponding thiuram disulfides. We also obtained more positive thiuram reactions to the monosulfides than to the disulfides. A positive reaction to a dithiocarbamate was accompanied by a positive reaction to the corresponding thiuram, except for 1 patient. The nitrogen substituents showed only minor differences between the methyl, ethyl and pentamethylene groups, but the butyl derivatives gave, in most cases, a negative response. Dialkylthiocarbamyl benzothiazole sulfides, formed between thiurams and mercaptobenzothiazoles during vulcanization, showed strong test reactions in almost all patients who were sensitive to dithiocarbamates, thiurams, or mercaptobenzothiazoles. Conclusions We found thiuram monosulfides to be better markers of thiuram sensitivity than the corresponding disulfides or dithiocarbamates. Surprisingly, the dialkylthiocarbamyl benzothiazole sulfides were good markers of both thiuram and mercaptobenzothiazole sensitivity. This is an unexpected finding that needs to be confirmed in a larger study.

Details

ISSN :
01051873
Volume :
70
Database :
OpenAIRE
Journal :
Contact Dermatitis
Accession number :
edsair.doi...........97ca3fcd5a18887ca1f3d13ec5d51305
Full Text :
https://doi.org/10.1111/cod.12168