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N-Hydroxymethylation of 3-Aryl-2-cyanoprop-2-enethioamides

Authors :
Sergey G. Krivokolysko
Victor V. Dotsenko
Elena A. Chigorina
Source :
Russian Journal of General Chemistry. 90:1411-1417
Publication Year :
2020
Publisher :
Pleiades Publishing Ltd, 2020.

Abstract

Hydroxymethylation of (E)-3-aryl-2-cyanoprop-2-enethioamides with an aqueous alcoholic solution of formaldehyde has afforded (E)-3-aryl-N-(hydroxymethyl)-2-cyanoprop-2-enethioamides. The predictive analysis of the biological activity of the obtained compounds in silico has been carried out.

Details

ISSN :
16083350 and 10703632
Volume :
90
Database :
OpenAIRE
Journal :
Russian Journal of General Chemistry
Accession number :
edsair.doi...........97c8a301470060163e1df45b5ba34ecd