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Abstract 16328: Residual Pulmonary Hypertension Persist Even in Patients With Successful MitraClip and Adversely Affect Heart Failure Events
- Source :
- Circulation. 130
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- Background: Pulmonary hypertension (PH) is common among patients requiring mitral valve treatment, and even mild PH adversely affect outcome. The aim of the study was to investigate the response of pulmonary artery pressure (PAP) in patients undergoing MitraClip and determine the prognostic effect of residual PH. Methods: From 2007 to 2013, 121 consecutive patients undergoing the MitraClip were retrospectively reviewed. Patients were categorized into two groups according to residual PH defined by post-procedural PAP obtained by transthoracic echocardiography. The primary endpoint was combined endpoints of all-cause mortality, left ventricular assist device implantation, shock, mitral valve surgery, New York Heart Association III-IV, re-hospitalization due to heart failure, new onset atrial fibrillation requiring hospitalization, ventricular arrhythmia, mechanical ventilation more than 48 hours, admission longer than two weeks. Patients with existing pulmonary disease or systemic disease affecting PAP were excluded. Results: Forty seven of 86 had residual PH. Patients with residual PH had higher pre-procedural PAP, and higher six months PAP than those without residual PH (pre-procedural, 50.3±13.4 vs 42.2±9.8 mmHg, p=0.003; at six months, 45.4±14.0 vs 34.7±9.9 mmHg, p Conclusion: Patients with residual PH have higher rate of adverse events associated with heart failure even with successful MR reduction, and additional medical intervention, such as pulmonary vasodilator, should be considered.
- Subjects :
- Mechanical ventilation
medicine.medical_specialty
Mitral regurgitation
business.industry
medicine.medical_treatment
MitraClip
medicine.disease
Pulmonary hypertension
medicine.anatomical_structure
Physiology (medical)
Ventricular assist device
Internal medicine
Mitral valve
Heart failure
medicine.artery
Pulmonary artery
medicine
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15244539 and 00097322
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi...........97be9d7668d8be2a0ab7468200bc9e79