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Cell-specific expression of key mitochondrial enzymes precludes OXPHOS in astrocytes of the adult human neocortex and hippocampal formation

Authors :
Arpad Dobolyi
Attila G Bago
Anna Stepanova
Krisztina Paal
Jeonghyoun Lee
Miklos Palkovits
Christos Chinopoulos
Publication Year :
2022
Publisher :
Cold Spring Harbor Laboratory, 2022.

Abstract

The astrocyte-to-neuron lactate shuttle hypothesis entails that glycolytically derived pyruvate in astrocytes is converted to lactate instead of being catabolized in mitochondria. The mechanism of this metabolic rewiring is unclear. Here we show that astrocytes of the adult human neocortex and hippocampal formation do not express mitochondrial proteins critical for performing oxidative phosphorylation (OXPHOS) to a detectable degree, including cytochrome c and complex IV. Without OXPHOS, human brain astrocytes are bound to produce lactate to avoid interruption of glycolysis.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........9799b620dd1288772f1c8a9bf2497cc7