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Enterolactone concentrations and prognosis after postmenopausal breast cancer: Assessment of effect modification and meta-analysis
- Source :
- International Journal of Cancer. 135:923-933
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- We previously reported that high concentrations of enterolactone, a lignan metabolite, are associated with lower mortality in 1,140 breast cancer patients from Germany. Using an extended set of 2,182 patients aged 50-74 years at diagnosis (2001-2005) and prospectively followed up until 2009, we investigated whether the association with mortality differs by lifestyle factors and tumor characteristics. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariable Cox regression. Potential differential effects by tumor characteristics and lifestyle factors were assessed and a meta-analysis of five studies addressing lignan exposure and breast cancer prognosis was performed to summarize evidence. Median enterolactone concentrations were 17.4 (± 30.5 standard deviation) and 22.9 nmol L(-1) (± 44.8), respectively, for 269 deceased and 1,913 patients still alive. High enterolactone concentrations were significantly associated with lower all-cause mortality (per 10 nmol L(-1) : HR 0.94, 95% CI 0.90-0.98), breast cancer-specific mortality (HR 0.94, 0.89-0.99), and distant disease-free survival (HR 0.94, 0.90-0.98). Associations were found for stage 0-IIIA but not for stage IIIB-IV disease (p(het) = 0.01) and were stronger in patients with BMI
- Subjects :
- Gynecology
Cancer Research
medicine.medical_specialty
business.industry
Proportional hazards model
Hazard ratio
Disease
medicine.disease
Gastroenterology
Confidence interval
chemistry.chemical_compound
Breast cancer
Oncology
Enterolactone
chemistry
Internal medicine
Meta-analysis
Medicine
Phytoestrogens
business
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi...........96e68a58163ecfab306b0c8036f6708d