Lumbar spinal stenosis in adult achondroplasia. An analysis of intervertebral disk alterations

Introduction/Background Lumbar spinal stenosis is a major contributor to disability in adults with achondroplasia. It arises from congenital dysplasia and acquired degenerative changes. The aim of the study was to characterize degenerative changes of the intervertebral disk in adult achondroplasia patients with lumbar spinal stenosis and to identify factors associated with the process. Material and method The study was a case series of adult achondroplasia patients. Clinical parameters were recorded. Radiographs were used to analyze spino-pelvic parameters. MRI of the lumbar spine was used to measure antero-posterior diameter of the canal and disk degeneration using the Pfirrmann grading system. Comparisons were done using the Kruskal–Wallis test and correlations using the Spearman coefficient. Results Eighteen patients were included: age 37 ± 17, female 12, size 127 ± 7 cm, weight 57 ± 13 kg. All had symptoms due to lumbar spinal stenosis. Antero-posterior diameters of the spinal canal differed according to level (P Conclusion Spinal stenosis and disk degeneration mainly involve the upper part of the lumbar spine in adult achondroplasia patients. Thoraco-lumbar kyphosis and lumbar lordosis are related with these processes. The findings may be of importance in rehabilitation and in early prevention of spinal stenosis in the course of achondroplasia.