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C2 symmetric amines. III. An asymmetric synthesis of (S,S)-1,3-dialkyl lsoindolines by sequential formamidine alkylation

Authors :
Braulio Santiago
Albert I. Meyers
Source :
Tetrahedron Letters. 36:5877-5880
Publication Year :
1995
Publisher :
Elsevier BV, 1995.

Abstract

Metalation-alkylation of isoindoline 5 in the form of its chiral formamidine, 6 leads to C 2 -dialkylated derivatives in high ee's.

Details

ISSN :
00404039
Volume :
36
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........9666c3b22d8163bbeac26dd900e0013f