Risk factors of Developing Symptomatic Myeloma from MGUS: analysis in our hospital

e102 Durie-Salmon Stage: IA: 9.8%, IB: 1.6%, II-A: 27.6%, IIB: 8.9%, III-A: 21.1%, III-B: 21.1%. ISS: I: 25.2%, II: 32.5%, III: 23.6%. The 21.1% of patients were not included in the analysis of response by uncompleted treatment. Response at end of therapy: minimal response: 5.1%, PR: 44.3%, VGPR: 16.5%, CR: 14.4% SR: 7.2%, Failure: 12.5%. During follow-up 65.7% patients, who achieved at least PR had clinical relapsed/progressed, in 86.9% of them, a previous EBR were detected at a mean of 4.4 months before; methods who detected BER: FLCr (28.8%), HLCr (13.5%), FLC+SPE+IFX (9.6%), FLC+IFX (5.8%), FLC+HLC+SPE (28.8%), FLC+HLC+SPE+UPE (5.7%) Median PFS 20 months (12.8-27.1) Biological PFS: 18 m (12.1-23.8). Conclusion: Both FLC and HLC are sensitive and accurate tools to perform MRD assessment response in MM, in our cohort a 42.3% of EBR were detected ahead of other techniques. More investigations on this field are warranted