Efficient syntheses of 3H-azuleno[8,1-cd]pyridazines and their thermal and photochemical reactions

Authors :: Tsung-Chieh Li
Hsien-Chung Chung
Rammohan Devulapally
Chi-Phi Wu
Chien-Kuo Ku
Source :: Tetrahedron Letters. 51:4819-4822
Publication Year :: 2010
Publisher :: Elsevier BV, 2010.
Abstract: Azulenopyridazines 6 were efficiently synthesized from ethyl 4-hydrazinylazulene-1-carboxylate (2) by p-toluenesulfonic acid-catalyzed imine formation and intramolecular cyclization followed by dehydrogenation using KOH/MeOH in one-pot operation. Thermal and photochemical reactions of azulenopyridazines 6 afforded 1-vinylazulenes 7 in good yields.

Subjects :: chemistry.chemical_compound
chemistry
Organic Chemistry
Drug Discovery
Imine
Thermal
Intramolecular cyclization
p-Toluenesulfonic acid
Dehydrogenation
Thermal reaction
Azulene
Photochemistry
Biochemistry

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