In situ characterization of lipidic bupivacaine-loaded formulations

This work details the in situ dynamical behaviour of local anaesthetic bupivacaine (BUP)-loaded L2 and H2 phase precursors (preformulations of BUP) upon rapid exposure to phosphate buffer under physiological conditions (pH 7.4, 37 °C). The hydration-induced structural transitions are characterized by time-resolved synchrotron SAXS.