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SARS-CoV-2 naïve and recovered individuals show qualitatively different antibody responses following mRNA vaccination

Authors :
Ramon Gimeno
Giuliana Magri
Leire de Campos-Mata
Carlo Carolis
Juan Navarro-Barriuso
Andrea Cerutti
José María Ramada
Natalia Rodrigo Melero
Clara Ribas-Llaurado
Sonia Tejedor Vaquero
Pilar Díaz
Publication Year :
2021
Publisher :
Cold Spring Harbor Laboratory, 2021.

Abstract

mRNA-based vaccines effectively induce protective neutralizing antibody responses against SARS-CoV-2, the etiological agent of COVID-19. The specific compositional patterns of these responses remain largely unknown. We found that SARS-CoV-2-naïve individuals receiving the first dose of an mRNA vaccine developed a SARS-CoV-2-specific antibody response with a subclass profile comparable to that induced by the natural infection, except IgA2, which did not increase. SARS-CoV-2-naïve subjects also mounted a robust virus-specific recall response after receiving the second dose. This response increased all IgG subclasses, but boosted neither IgM nor IgA1 and IgA2 subclasses. In contrast, individuals recovered from COVID-19 mounted peak virus-specific antibody responses upon primary immunization and did not further augment such responses following secondary immunization. Remarkably, compared to SARS-CoV-2-naïve subjects, individuals with pre-existing immunity showed increased levels of all virus-specific antibodies but IgG3 following primary vaccination. By dissecting the heterogeneity of mRNA vaccine-induced humoral responses to SARS-CoV-2, our findings indicate that the induction of optimal immune protection may require the development of personalized vaccination programs.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........96280b9b4f2da8e06381ed974fe8c2df
Full Text :
https://doi.org/10.1101/2021.05.07.21256821