Progestational Activity of 6 -Methyl-17 -Acetoxyprogesterone

Summary1) 6α-methyl-17α-acetoxyprogesterone is a highly active progestin based on its ability to promote a secretory endometrium and to prevent ovulation in rabbits. 2) Subcutaneously, 6α-methyl-17α-acetoxyprogesterone is 6 to 8 times and orally 60 to 75 times as active as 17α-acetoxyprogesterone in the McPhail assay. The ability of the 6-methyl compound to inhibit ovulation in rabbits is at least 20 times as great as that of progesterone subcutaneously, while 17α-acetoxyprogesterone is 7 times as active as progesterone.