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Effect of LED light spectra on exogenous prolactin-regulated circadian rhythm in goldfish,Carassius auratus
- Source :
- Biological Rhythm Research. 46:121-135
- Publication Year :
- 2014
- Publisher :
- Informa UK Limited, 2014.
-
Abstract
- We investigated the effect of light spectra on circadian rhythm by exogenous prolactin (PRL) using light-emitting diodes (LEDs): red, green and purple. We injected PRL into live fish or treated cultured brain cells with PRL. We measured changes in the expressions of period 2 (Per2), cryptochrome 1 (Cry1), melatonin receptor 1 (MT1) mRNAs, and MT1 proteins, and in the plasma PRL, serotonin and melatonin levels. After PRL injection and exposure to green light, MT1 expression and plasma melatonin levels were significantly lower, but the expressions of Per2 and Cry1 were significantly higher than the others. Plasma serotonin after PRL injection and exposure to red light was significantly lower than others. These results indicate that injection of high concentration PRL inhibits melatonin, and inhibited melatonin regulates circadian rhythm via clock genes and serotonin. Thus, exogenous PRL regulates the circadian rhythm and light spectra influence the effect of PRL in goldfish.
- Subjects :
- endocrine system
medicine.medical_specialty
endocrine system diseases
Physiology
Period (gene)
Biology
Melatonin receptor
Prolactin
Melatonin
CLOCK
PER2
Endocrinology
Physiology (medical)
Internal medicine
medicine
Circadian rhythm
hormones, hormone substitutes, and hormone antagonists
Ecology, Evolution, Behavior and Systematics
Cryptochrome-1
medicine.drug
Subjects
Details
- ISSN :
- 17444179 and 09291016
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Biological Rhythm Research
- Accession number :
- edsair.doi...........95f3f24176597c4e005bb01d61b96b81