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Prone position decreases acute lung inflammation measured by [11C](R)-PK11195 positron emission tomography in experimental acute respiratory distress syndrome

Authors :
François Dhelft
Sophie Lancelot
William Mouton
Didier Le Bars
Nicolas Costes
Emmanuel Roux
Maciej Orkisz
Nazim Benzerdjeb
Jean-Christophe Richard
Laurent Bitker
Source :
Journal of Applied Physiology. 134:467-481
Publication Year :
2023
Publisher :
American Physiological Society, 2023.

Abstract

Prone position decreases acute lung macrophage inflammation quantified in vivo with [11C](R)-PK11195 positron emission tomography in an experimental acute respiratory distress syndrome. Regional macrophage inflammation is maximal in the most anterior and posterior lung section of supine animals, in relation with increased regional tidal strain and hyperinflation, and reduced regional lung compliance.

Subjects

Subjects :
Physiology
Physiology (medical)

Details

ISSN :
15221601 and 87507587
Volume :
134
Database :
OpenAIRE
Journal :
Journal of Applied Physiology
Accession number :
edsair.doi...........954b3551ad695413605ebc92027770a0
Full Text :
https://doi.org/10.1152/japplphysiol.00234.2022