The synthesis and biological properties of [I-deaminopenicillamine]-oxytocin deuterated in the I-position

This paper describes the synthesis of 3- S -benzylmercapto-3-methyl- d 8 -butanoic-2,2,4,4,4- d 5 acid ( S -benzyl-deaminopenicillamine- d s ) and [1-deaminopenicillamine- d s ]-oxytocin. Within experimental error the deuterated oxytocin analog possessed the same anti-oxytocic activity as the protio derivative [1-deaminopenicillamine]-oxytocin.