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WITHDRAWN: Molecular genetics of thrombotic myeloproliferative neoplasms: Implications in precision oncology
- Source :
- Genes & Diseases.
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Classical BCR-ABL-negative myeloproliferative neoplasms (MPN) include polycythaemia vera, essential thrombocythaemia and primary myelofibrosis. Unlike monogenic disorders, a more complicated series of genetic mutations are believed to be responsible for MPN with various degrees of thromboembolic and bleeding complications. Thrombosis is one of the early manifestations in patients with MPN. To date, the driver genes responsible for MPN include JAK2, CALR, MPL, TET2, ASXL1 and MTHFR. Affords have been done to elucidate these mutations and the incidence of thromboembolic events. Several lines of evidence indicate that mutations in JAK2, MPL, CALR, TET2 and ASXL1 gene and polymorphisms in several clotting factors (GPIa, GPIIa and GPIIIa) are associated with the occurrence and prevalence of thrombosis in MPN patients. Some polymorphisms within XRCC1, FBG, F2, F5, F7, F12, MMP9, HPA5, MTHFR, SDF-1, FAS, FASL, TERT, ACE and TLR4 genes may also play a role in MPN manifestation. This review aims to provide an insightful overview on the genetic perspective of thrombotic complications in patients with MPN.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Polycythaemia
Bioinformatics
Biochemistry
03 medical and health sciences
XRCC1
0302 clinical medicine
hemic and lymphatic diseases
Molecular genetics
medicine
Myelofibrosis
Molecular Biology
Genetics (clinical)
Clotting factor
biology
business.industry
Incidence (epidemiology)
food and beverages
Cell Biology
medicine.disease
Thrombosis
030104 developmental biology
030220 oncology & carcinogenesis
Methylenetetrahydrofolate reductase
biology.protein
business
Subjects
Details
- ISSN :
- 23523042
- Database :
- OpenAIRE
- Journal :
- Genes & Diseases
- Accession number :
- edsair.doi...........94fb2ad93c441ce7074484fb4437ac90