Back to Search
Start Over
The Effects of Sex and Estrogen on Radiographic Progression of Ankylosing Spondylitis in Korean Patients
- Source :
- Journal of Rheumatic Diseases. 28:76-84
- Publication Year :
- 2021
- Publisher :
- Korean College of Rheumatology, 2021.
-
Abstract
- Objective. Ankylosing spondylitis (AS) is a chronic inflammatory disease with obvious male preponderance. Males show more severe radiographic manifestations compared with females. This study aimed to evaluate the effects of sex and estrogen on the radiographic progression of AS. Methods. A total of 101 patients with AS were included in this study. All of the radiographs were scored using the modified Stoke AS Spine Score (mSASSS). Serum levels of 17β-estradiol (E2), dickkopf-1 (Dkk1), and leptin were detected by enzyme-linked immunosorbent assay. The generalized estimating equations model was used to evaluate factors associated with spinal radiographic progression. Results. The mean age at disease onset was 27.3±10.7 years, and 16 patients (15.8%) were female. In the multivariable analysis, body mass index (β-coefficient=0.12; p=0.047) and levels of Dkk1 (β-coefficient=-0.11; p<0.001), and female (β-coefficient=-1.40; p=0.001) were associated with radiographic progression. Among male patients with AS, baseline C-reactive protein (β=0.11; p=0.005) and mSASSS (β=0.21; p=0.030) were also associated with radiographic progression. E2 and leptin levels were not significantly related to the radiographic progression. Conclusion. Although female patients were associated with less radiographic progression in AS, there was no significant relationship between serum estrogen level and radiographic progression. Results of current study suggests that genetic factors or other environmental factors associated with female may influence radiographic progression in patients with AS. (J Rheum Dis 2021;28:76-84)
- Subjects :
- 0303 health sciences
medicine.medical_specialty
Ankylosing spondylitis
030219 obstetrics & reproductive medicine
business.industry
medicine.drug_class
Radiography
Leptin
medicine.disease
Gastroenterology
03 medical and health sciences
Serum estrogen
0302 clinical medicine
Rheumatology
Estrogen
Internal medicine
medicine
In patient
business
Generalized estimating equation
Body mass index
030304 developmental biology
Subjects
Details
- ISSN :
- 22334718 and 2093940X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Rheumatic Diseases
- Accession number :
- edsair.doi...........94f0b09e0d639be23f9231a9ebed5505