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ChemInform Abstract: A Practical Synthesis of 4-Amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine
- Source :
- ChemInform. 47
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- The title compound (II), a key intermediate for the synthesis of the anti-psychotic drug olanzapine, is prepared by intramolecular cyclocondensation of [(nitrophenyl)amino]thiophenecarbonitrile (I) using tin powder and HCl a reducing system.
Details
- ISSN :
- 09317597
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........94ec532c18eced3c1666a0b1afaaa753
- Full Text :
- https://doi.org/10.1002/chin.201652361