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Clinical Procedure of Cell Therapy: Separation and Infusion
- Source :
- Cell Therapy for Perinatal Brain Injury ISBN: 9789811014116
- Publication Year :
- 2018
- Publisher :
- Springer Singapore, 2018.
-
Abstract
- Umbilical cord blood (UCB) cells could be a useful adjunct intervention for infants with HIE. We report our clinical experience of UCB stem cell transplantation in infants with HIE. We selected patients for UCB stem cell transplantation based on following criteria; (1) moderate or severe HIE according to the classification of Sarnat II or III and Thompson score ≥10 points, (2) gestational age ≥36 weeks, (3) body weight at birth >1800 g, (4) born by cesarean section under general anesthesia, and (5) inborn baby. Cases in which collected UCB volume is below 40 mL were excluded from this trial. Brain hypothermia therapy (BHT) was performed simultaneously under supportive mechanical ventilation with sedative agents (fentanyl citrate and midazolam). After collected UCB, CD34-positive cells were separated by SEPAX-2™ (Biosafe SA, Eysins/Nyon, Switzerland) and were transfused to the babies once a day for 12 h to 3 days.
- Subjects :
- Mechanical ventilation
business.industry
medicine.drug_class
medicine.medical_treatment
Gestational age
Hypothermia
Umbilical cord
Transplantation
fluids and secretions
medicine.anatomical_structure
Anesthesia
Sedative
embryonic structures
medicine
Midazolam
Stem cell
medicine.symptom
business
medicine.drug
Subjects
Details
- ISBN :
- 978-981-10-1411-6
- ISBNs :
- 9789811014116
- Database :
- OpenAIRE
- Journal :
- Cell Therapy for Perinatal Brain Injury ISBN: 9789811014116
- Accession number :
- edsair.doi...........94e7b297adc604f1340c00c9190f41eb