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Correlation Between Serum Total Bilirubin Levels and Blood Pressure Variability in Patients With Hypertension

Authors :
Jun Wang
Xian-ping Wang
Jing-shui Zhang
Long Tang
Long Hu
Ya-nan Xu
Ming-liang Shao
Zhen Li
Source :
American Journal of Hypertension. 34:1009-1010
Publication Year :
2021
Publisher :
Oxford University Press (OUP), 2021.

Abstract

Background To investigate the effect of serum total bilirubin levels on blood pressure and its variability in patients with hypertension. Methods This study was a retrospective observational study. A total of 189 subjects were recruited from September 2019 to March 2020. All hypertensive patients were scheduled for ambulatory blood pressure and a 24-hour dynamic electrocardiography. Standard deviations of 24-hour systolic and diastolic blood pressure were used as blood pressure variability indicators. A multiple linear regression was used to analyze the relationship between total bilirubin serum levels and blood pressure variability in hypertensive patients. Results All patients were divided into 3 groups according to tertile values of total bilirubin: low (≤12.2 µmol/l, n = 64), moderate (12.3–16.7 µmol/l, n = 64), and high (>16.8 µmol/l, n = 62) total bilirubin groups. Compared with low total bilirubin group, 24-hour mean systolic and diastolic blood pressure, 24-hour systolic blood pressure standard deviation, systolic blood pressure coefficient of variability, and 24-hour systolic blood pressure load were reduced in the moderate and high total bilirubin groups (all P < 0.05). Multiple linear regression analysis showed that female (B = −1.408, P = 0.013), age (B = 0.043, P = 0.035), diabetes (B = 2.624, P < 0.001), and moderate and high bilirubin grouping (B = −1.582, −3.079; both P < 0.05) were influencing factors of 24-hour systolic pressure standard deviation. Serum total bilirubin levels had no effect on the standard deviation of 24-hour diastolic blood pressure(P > 0.05). Conclusions In hypertensive patients, the total bilirubin serum level is an influencing factor for 24-hour systolic blood pressure variability.

Details

ISSN :
19417225 and 08957061
Volume :
34
Database :
OpenAIRE
Journal :
American Journal of Hypertension
Accession number :
edsair.doi...........94789994b77de507b8a5498f01917623