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A Model for the Architecture of α-Crystallin
- Source :
- Ophthalmic Research. 11:441-452
- Publication Year :
- 1979
- Publisher :
- S. Karger AG, 1979.
-
Abstract
- Knowledge of the quaternary structure of α-crystallin is required to understand the age-dependent superaggregation processes, eventually leading to lens opacification. Different approaches, e.g. sulfhydryl modification, chemical cross-linking, limited proteolysis and dissociation studies revealed new information, providing a basis for further studies of aging and higher-order structures. A model for the architecture of native α-crystallin from calf lens cortex, featuring subunit arrangement and surface exposure, will be presented.
Details
- ISSN :
- 14230259 and 00303747
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Ophthalmic Research
- Accession number :
- edsair.doi...........945340ff2ca16753659c589c42a5a6c8